Fc (human):FGL1 (mouse) (rec.) - 深圳欣博盛生物科技有限公司

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Fc (human):FGL1 (mouse) (rec.)

品牌： Adipogen

产品货号： AG-40B-0185-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

Fc (human):FGL1 (mouse) (rec.)
别名:

Fibrinogen-like Protein 1; FGL-1; Hepatocyte-derived Fibrinogen-related Protein 1; HFREP-1; Hepassocin
产品描述:

FGL1 (Fibrinogen-like protein 1; also called Hepatocyte-derived fibrinogen-related protein 1; HFREP-1 or Hepassocin) was initially identified as an overexpressed transcript in hepatocyte carcinoma and as a transcript enriched in regenerating liver. FGL1 is expressed at lower levels in brown and white adipose in the setting of liver injury. A low level expression of FGL1 is also observed in the pancreas. FGL1 is a 34 kDa protein structurally similar to Angiopoietin-like factors 2, 3, 4 and 6, which regulate lipid metabolism and energy utilization. It was proposed that FGL1 is a member of an emerging group of proteins having potential roles in liver metabolism and liver regeneration. Recently, FGL1 has also been shown to be upregulated in human cancers and FGL1 is a major functional ligand of LAG-3. FGL1 interacts with LAG-3 in an MHC-II-independent manner and this interaction involves the FGL1 fibrinogen-like domain and the LAG-3 D1-D2 domain. FGL1-LAG-3 interaction blockade promotes tumor immunity by stimulating T cell expansion and activation. FGL1 forms two disulfide-linked homodimers and also higher molecular weight homooligomers that bind to LAG-3 much better than the dimeric forms. This binding to LAG-3 inhibits T cell responses. The recombinant fusion protein Fc (human):FGL1 (human) (FGL1-Ig) has been shown to function as an efficient ligand of LAG-3.
反应种属:
宿主来源:

HEK 293 cells
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免疫原:
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产品浓度:

After reconstitution:for 10µg size: 0.1mg/mlfor 100µg size: 1mg/ml
表达系统:
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保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:

~68kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized. Contains PBS.
有效期:

Stable for at least 6 months after receipt when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized. Contains PBS.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:

Should activate mouse LAG-3 (activity test not yet performed).
内毒素水平:

<0.01EU/µg purified protein (LAL test).
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