CD112R (mouse):Fc (human) (rec.) MultiPack - 深圳欣博盛生物科技有限公司

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CD112R (mouse):Fc (human) (rec.) MultiPack

品牌： Adipogen

产品货号： AG-40B-0170-3010

规格： 3 x 10 ug

报价：

折后价：

数量： - +

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产品名称:

CD112R (mouse):Fc (human) (rec.) MultiPack
别名:

CD112 Receptor; Poliovirus Receptor-related Immunoglobulin Domain-containing Protein; Transmembrane Protein PVRIG
产品描述:

CD112 (also called Nectin-2 or poliovirus receptor-related 2 protein) is a type I transmembrane glycoprotein and a member of the Ig gene superfamily (IGSF). CD112/Nectin-2 functions as an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2 is a also a surface marker of some endothelial cells and regulates migration, proliferation and angiogenesis. CD112 functions as an immune checkpoint regulator by modulating T cell signaling, either as a costimulator of T cell function, or as a coinhibitor of T cells proliferation by binding to the receptors CD226 or TIGIT (T cell Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain), respectively. The binding of CD112 ligand to these receptors is weak compared to CD155. Recently, a new receptor of CD112, called CD112R or PVRIG (Poliovirus receptor-related immunoglobulin domain-containing protein) has been characterized, showing high affinity to CD112. CD112R is a new coinhibitory receptor of the PVR family for human T cells, inhibiting TCR-mediated signals upon binding to CD112/Nectin-2. CD112R is preferentially expressed in T lymphocytes and NK cells. Cancer cells evade immune responses as a result of an immunosuppressive tumor microenvironment and CD112R, by playing a role in the regulation of the immune system, could be a new attractive cancer immunotherapy target.
反应种属:
宿主来源:

HEK 293 cells
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同种型:
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免疫原:
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产品浓度:

0.1mg/ml after reconstitution
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:

~48-50kDa (SDS-PAGE)
产品形式:

solid
存储溶液:

Lyophilized. Contains PBS.
有效期:

Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:

瑞士
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样本类型:

Lyophilized. Contains PBS.
产品特点:
纯度:

>90% (SDS-PAGE)
生物活性:

Binds to the ligand mouse CD112 (PVRL2, Nectin-2) with an EC50 of 5nM.
内毒素水平:

<0.01EU/µg purified protein (LAL test).
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