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Fc (human):Dectin-1 (mouse) (rec.)
品牌： Adipogen
产品货号： AG-40B-0138-C050
规格： 50 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    Fc (human):Dectin-1 (mouse) (rec.)
  • 别名:
    C-type Lectin Domain Family 7 Member A; Beta-Glucan Receptor; Dendritic Cell-associated C-type Lectin 1; C-type Lectin Superfamily Member 12; DC-associated C-type Lectin 1
  • 产品描述:
    Dectin-1 and dectin-2 are type II transmembrane proteins of the C-type lectin family. They contain single carbohydrate recognition domains (CRDs) in their extracellular region. Dectin-1 and dectin-2 are expressed in macrophages and dendritic cells. Dectin-1 recognizes beta-glucans with its CRD and signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domain, whereas dectin-2 recognizes alpha-mannans and transduces its signal through association with the ITAM-containing Fc receptor gamma-chain. Dectin-1 controls fungal infection by sensing beta-glucans and by mounting a Th17-mediated immune responses. Dectin-1 seems to detect also non-fungal ligands such as invertebrate tropomyosin. Dectin-1 by binding to non-fungal ligands controls type 2 immunity in the lungs in response to the dust mite aeroallergen through the regulation of IL-33-driven IL-13 production from innate lymphoid cells.
  • 反应种属:
  • 宿主来源:
    HEK 293 cells
  • 实验应用:
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  • 免疫原:
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  • 偶联:
  • 产品浓度:
    1mg/ml after reconstitution
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
    ~56kDa (SDS-PAGE)
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized. Contains PBS.
  • 有效期:
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
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  • 样本类型:
    Lyophilized. Contains PBS.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
  • 内毒素水平:
    <0.01EU/µg purified protein (LAL test).
  • 来源:
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