您好,欢迎光临欣博盛生物科技商城!
服务热线:400 680 0892
SARS-CoV-2 Spike Protein S1 (RBD):Fc (human) (rec.) (P.1 Variant, Gamma)
品牌: Adipogen
产品货号: AG-40B-0204-C050
规格: 50 ug

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    SARS-CoV-2 Spike Protein S1 (RBD):Fc (human) (rec.) (P.1 Variant, Gamma)
  • 别名:
    2019-nCoV Spike Protein S1 (RBD); Spike Receptor Binding Domain Variant Brazil, B.1.1.248; 20J/501Y.V3; VOC-202101/02
  • 产品描述:
    SARS-CoV-2 shares 79.5% sequence identity with SARS-CoV and is 96.2% identical at the genome level to the bat coronavirus BatCoV RaTG133, suggesting it had originated in bats. The coronaviral genome encodes four major structural proteins: the Spike (S) protein, Nucleocapsid (N) protein, Membrane/Matrix (M) protein and the Envelope (E) protein. The SARS Envelope (E) protein contains a short palindromic transmembrane helical hairpin that seems to deform lipid bilayers, which may explain its role in viral budding and virion envelope morphogenesis. The SARS Membrane/Matrix (M) protein is one of the major structural viral proteins. It is an integral membrane protein involved in the budding of the viral particles and interacts with SARS Spike (S) protein and the Nucleocapsid (N) protein. The N protein contains two domains, both of them bind the virus RNA genome via different mechanisms. The CoV Spike (S) protein assembles as trimer and plays the most important role in viral attachment, fusion and entry. It is composed of a short intracellular tail, a transmembrane anchor and a large ectodomain that consists of a receptor binding S1 subunit (RBD domain) and a membrane-fusing S2 subunit. The S1 subunit contains a receptor binding domain (RBD), which binds to the cell surface receptor angiotensin-converting enzyme 2 (ACE2) present at the surface of epithelial cells. Recently, a new variant of SARS-CoV-2, called P.1 (Gamma) was detected in Brazil. This variant carries three mutations in the RBD at the positions 417, 484 and 501 (K417T, E484K, N501Y). The P.1 or Brazilian variant is a form of the SARS-CoV-2 coronavirus that appears to have evolved in Brazil and might have contributed to a surge in cases in the northern city of Manaus.
  • 反应种属:
  • 宿主来源:
    HEK 293 cells
  • 实验应用:
  • 靶标/特异性:
  • 同种型:
  • 推荐稀释度:
  • 免疫原:
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
  • 纯化方式:
  • 偶联:
  • 产品浓度:
    1mg/ml after reconstitution
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
    ~60kDa (SDS-PAGE); ~115 kDa (Dimer) (SEC)
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized. Contains PBS.
  • 有效期:
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Lyophilized. Contains PBS.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
    Binds to human ACE2.
  • 内毒素水平:
    <0.01EU/µg purified protein (LAL test).
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
关注欣博盛公众号
Copyright ©2021 - 2023 深圳欣博盛生物科技有限公司
  网站地图
犀牛云提供企业云服务