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Animal-Free Recombinant Human sRANK Ligand (E.coli derived)
品牌： PeproTech
产品货号： AF-310-01-2ug
规格： 2ug

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数量： - +
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  • 产品名称:
    Animal-Free Recombinant Human sRANK Ligand (E.coli derived)
  • 别名:
    soluble Receptor Activator of NF-kappaB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)
  • 产品描述:
    RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naive T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Human RANKL is reactive on murine cells. Recombinant Human sRANK Ligand is a 20.0 kDa polypeptide comprising the TNF-homologous region of RANKL (176 amino acid residues).
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    E.coli
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  • 推荐稀释度:
    请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
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    20 kDa
  • 产品形式:
    Standard
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  • 产地:
    美国
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