Animal-Free Recombinant Human C5a - 深圳欣博盛生物科技有限公司

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Animal-Free Recombinant Human C5a

品牌： PeproTech

产品货号： AF-300-70-250ug

规格： 250ug

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数量： - +

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产品名称:

Animal-Free Recombinant Human C5a
别名:

Complement Component 5a, Complement 5a, CPAMD4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
产品描述:

Complement 5a (C5a) is an enzymatically generated glycoprotein belonging to the anaphylatoxin family of structurally and functionally related proteins. Generated upon the activation of the complement system, C5a, together with C4a, C3a, and the membrane attack complex (C5b-9), functions as a central player in host defense by inducing smooth muscle cell contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes through cell degranulation. In addition to acting as a direct mediator of localized inflammatory response, C5a also initiates both the synthesis and release of IL-8 from monocytes and bronchial epithelial cells, stimulates the proliferation of neurons and hepatocytes, and functions as a potent chemoattractant. Where C5a deficiency, a rare defect of the complement pathway caused by the mutation of the C5a gene, is associated with susceptibility to severe infections, excessive C5a activation has been linked to liver fibrosis, sepsis, adult respiratory distress syndrome, rheumatoid arthritis, Alzheimer's disease, and ischemic heart disease. Human C5a shares 60% and 54% sequence identity to mouse and rat C5a, respectively. The human C5 gene encodes a 1,676 amino acid glycoprotein that is comprised of a disulfide-linked C5 alpha and a C5beta chain, the former of which contains the active, 74 amino acid C5a anaphylatoxin chain. Recombinant Human C5a is an 8.3 kDa glycoprotein containing the 74 amino acid residues of the C5a anaphylatoxin chain.
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E.coli
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请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
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8.3 kDa
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Bulk
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美国
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