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IL-21 (human) (rec.) (untagged)
品牌： Adipogen
产品货号： CHI-HR-20621-C010
规格： 10 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    IL-21 (human) (rec.) (untagged)
  • 别名:
    Interleukin-21
  • 产品描述:
    Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naïve T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumors, leading to tumor rejection that is perforin dependent but IFN-gamma independent.
  • 反应种属:
  • 宿主来源:
    E. coli
  • 实验应用:
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  • 产品浓度:
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -80°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
    ~17kDa (SDS-PAGE)
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized from 0.2µm-filtered solution in PBS.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -80°C. Working aliquots are stable for up to 3 months when stored at -20°C.
  • 产地:
    瑞士
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  • 检测方法:
  • 样本类型:
    Lyophilized from 0.2µm-filtered solution in PBS.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
    Measured by its ability to induce interferon-gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is 0.4-2ng/ml.
  • 内毒素水平:
    <0.01EU/µg protein (LAL test; Lonza).
  • 来源:
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