IL-15 (mutant) (human):Fc (mouse) (rec.) (Biotin) - 深圳欣博盛生物科技有限公司

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IL-15 (mutant) (human):Fc (mouse) (rec.) (Biotin)

品牌： Adipogen

产品货号： CHI-HF-21115MBI-1

规格： 1 Vial

报价：

折后价：

数量： - +

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产品名称:

IL-15 (mutant) (human):Fc (mouse) (rec.) (Biotin)
别名:

Interleukin-15
产品描述:

Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumor mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumor antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumor-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumor effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumor vaccines. Application: Useful for immunofluorescent staining and flow cytometric analysis to identify and enumerate IL-15Ralpha expressing cells within mixed cell populations.
反应种属:
宿主来源:

CHO cells
实验应用:
靶标/特异性:
同种型:
推荐稀释度:
免疫原:
免疫原种属:
克隆性:
克隆号:
纯化方式:
偶联:

Biotin
产品浓度:
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

solid
存储溶液:

Lyophilized. In PBS and 0.09% sodium azide.
有效期:

Stable for at least 6 months after receipt when stored at +4°C.
产地:

瑞士
外观:
生产商:
功能与背景:
URL:
灵敏度:
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样本类型:

Lyophilized. In PBS and 0.09% sodium azide.
产品特点:
纯度:

>98% (SDS-PAGE)
生物活性:

This mutant IL-15/Fc fusion protein specifically binds to the IL-15R, competitively inhibits IL-15-triggered cell proliferation, promotes transplant tolerance, does not activate the STAT-signaling pathway, and exerts a prolonged circulating half-life caused by the modified Fc domain.
内毒素水平:

<0.06EU/µg protein (LAL test; Lonza).
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