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IL-36gamma (aa 13-164) (mouse) (rec.) (untagged)
品牌： Adipogen
产品货号： AG-40B-0100-C010
规格： 10 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    IL-36gamma (aa 13-164) (mouse) (rec.) (untagged)
  • 别名:
    Interleukin-36gamma; Interleukin-1 Family Member 9; IL-1F9
  • 产品描述:
    IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.
  • 反应种属:
  • 宿主来源:
    E. coli
  • 实验应用:
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  • 产品浓度:
    0.1mg/ml after reconstitution
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
    ~17kDa
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized. Contains PBS + 0.5% Trehalose.
  • 有效期:
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
  • 产地:
    瑞士
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  • 样本类型:
    Lyophilized. Contains PBS + 0.5% Trehalose.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
    Induces secretion of IL-6 in BMDCs.
  • 内毒素水平:
    <0.01EU/µg purified protein (LAL test; Lonza).
  • 来源:
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