Isthmin-1 (human) ELISA Kit - 深圳欣博盛生物科技有限公司

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Isthmin-1 (human) ELISA Kit

品牌： Adipogen

产品货号： AG-45B-0032-KI01

规格： 96 wells

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产品名称:

Isthmin-1 (human) ELISA Kit
别名:

C20orf82; ISM1; ISM
产品描述:

Isthmin-1 (ISM1) was first identified as a gene expressed in the Xenopus midbrain-hindbrain organizer called the isthmus, with a proposed role during early brain development. Isthmin-1 encodes a predicted ~50-kDa protein containing a signal peptide, a thrombospondin domain and an adhesion-associated domain. Isthmin-1 is important for embryonic and postnatal development. Growing evidence has shown that aberrant expression of Isthmin-1 can also affect the biological behavior of cancer. The Ism1 gene is conserved in mice and humans. A recent study showed that Isthmin-1 is an adipokine that induces glucose uptake in human and mouse adipocytes. Mature adipocytes secrete isthmin-1 and trigger a signaling cascade similar to that of insulin, regulating glucose uptake while suppressing lipid accumulation. Recombinant Isthmin-1 or overexpression of Isthmin-1 causes a robust increase in GLUT4-dependent glucose uptake in cultured primary murine and immortalized human adipocytes as well as in primary human muscle cells and prevents insulin resistance and hepatic steatosis in a diet-induced obesity mouse model. Ablation of Isthmin-1 causes glucose intolerance and impaired insulin-stimulated adipocyte glucose uptake. Isthmin-1 suppresses de novo lipogenesis and increases protein synthesis in hepatocytes whereas Isthmin-1 knockdown in adipocytes reduces glucose uptake and insulin-dependent phosphorylation of protein kinase AKT at serine residue 473 (p-AKTSer473). Isthmin-1 signaling is dependent on PI3K and shares downstream phosphorylation targets with insulin signaling, such as p-AKTSer473, p-AKTThr308, p-ERK1/2Thr202/Tyr204 and p-S6Ser235/236. Isthmin-1 does not seem to act through the insulin receptor or the insulin-like growth factor 1 receptor; it is most likely to signal through another, yet-to-be-identified, receptor tyrosine kinase. Isthmin-1 levels positively correlate with obesity in human plasma and are also associated with T-cell depletion markers (PD-1, LAG-3, TIM-3 or CTLA-4), suggesting its use as a biomarker during immunotherapy.
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+4°C
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BLUE ICE
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solid
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有效期:

12 months after the day of manufacturing. See expiry date on ELISA Kit box.
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瑞士
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