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SREBP-1 Transcription Factor Assay Kit
品牌： Cayman
产品货号： 10010854
规格： 96 wells

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数量： - +
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  • 产品名称:
    SREBP-1 Transcription Factor Assay Kit
  • 别名:
    Sterol Regulatory Element-Binding Protein-1 Assay Kit
  • 产品描述:
    Three known isoforms of SREBP (sterol regulatory element binding protein) transcription factors have been characterized: SREBP-1a, SREBP-1c, and SREBP-2. SREBP-1c acts primarily to activate genes required for fatty acid synthesis, such as acetyl-CoA carboxylase, fatty acid synthase, and long chain fatty acid elongase. In addition, SREBP-1c may also contribute to the regulation of glucose uptake and synthesis through induction of glucokinase. SREBP-1c has important clinical implications in the treatment of many diseases including obesity, diabetes mellitus, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Cayman’s SREBP-1 Transcription Factor Assay is a non-radioactive, sensitive method for detecting specific transcription factor DNA binding activity. SREBP-1 contained in nuclear extracts and whole cell lysates binds to a dsDNA SREBP response element immobilized to the wells of a 96-well plate. SREBP-1 is detected by addition of a specific primary antibody directed against SREBP-1. A secondary antibody conjugated to HRP is used to provide a sensitive colorimetric readout at 450 nm.
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  • 保存温度:
    -80
  • 运输温度:
    -80
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  • 有效期:
    365
  • 产地:
    美国
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    Animal/Rabbit|Animal/Goat|Animal/Bovine
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