Influenza A H1N1 (Swine Flu 2009) HA Monoclonal Antibody (Clone 9G1G8)

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品牌： Cayman

产品货号： 39541-100 µl

规格： 100 µl

报价：

折后价：

数量： - +

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产品名称:

Influenza A H1N1 (Swine Flu 2009) HA Monoclonal Antibody (Clone 9G1G8)
别名:

Influenza A H1N1 (Swine Flu 2009) Hemagglutinin
产品描述:

Influenza A H1N1 HA is a type I membrane glycoprotein involved in receptor binding and virus-host cell fusion.{69220,69221} It is produced as a precursor protein, HA0, which is composed of a stalk and head domain and forms homotrimers on the viral surface.{69222,69220} The HA0 precursor is cleaved into subunits, HA1 and HA2, which are responsible for host cell surface receptor binding and endosomal membrane fusion, respectively, and this cleavage is required for endosomal fusion.{69220} For influenza A and influenza B, which are low pathogenic influenza viruses, cleavage occurs via trypsin-like proteases, such as transmembrane serine protease 2 (TMRPSS2), which is essential for influenza A HA, but not influenza B HA, cleavage.{69223,69224,69225} Cleaved influenza A H1N1 HA binds to terminal α2,6- or α2,3-sialic acids on glycoproteins or glycolipids on the host cell surface via the receptor-binding domain in the HA1 subunit, which triggers endocytosis of the virus and trafficking of the vesicle into the endosome.{69222,69226,69227} The low pH environment of the endosome triggers viral rearrangement into a prefusion conformation, and the HA2 subunit facilitates fusion with the endosomal membrane to release viral ribonucleoproteins into the cytosol where they are relocated to the nucleus for viral replication.{69222} Cayman’s Influenza A H1N1 (Swine Flu 2009) HA Monoclonal Antibody (Clone 9G1G8) can be used for ELISA and Western blot (WB) applications.
反应种属:
宿主来源:

Mouse
实验应用:

ELISA, WB
靶标/特异性:
同种型:

IgG2b
推荐稀释度:
免疫原:

Recombinant influenza A H1N1 (Swine Flu 2009) HA
免疫原种属:
克隆性:
克隆号:

9G1G8
纯化方式:
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保存温度:

4
运输温度:

4
细胞定位:
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产品形式:

20 or 100 µl of protein A-affinity purified monoclonal antibody
存储溶液:
有效期:

365
产地:

美国
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