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产品名称:
SKP2 antibody
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别名:
S-phase kinase associated protein 2 , FBL1 , FBXL1 , FLB1 , p45
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产品描述:
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反应种属:
Human, Mouse, Rat
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宿主来源:
Rabbit
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实验应用:
ICC/IF, WB
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靶标/特异性:
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同种型:
IgG
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推荐稀释度:
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免疫原:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SKP2 (NP_005974.2).
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免疫原种属:
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克隆性:
Polyclonal
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克隆号:
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纯化方式:
Purified by affinity chromatography
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偶联:
Unconjugated
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产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
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表达系统:
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阳性对照:
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保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
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运输温度:
4°C
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细胞定位:
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预期分子量:
48
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产品形式:
Liquid
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存储溶液:
PBS pH7.3, 50% Glycerol
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有效期:
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产地:
美国
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外观:
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生产商:
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功能与背景:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
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URL:
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检测方法:
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样本类型:
PBS pH7.3, 50% Glycerol
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纯度:
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PubChem CID: