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anti-RasGRP2 (phosphorylated) (pSer587), pAb (IG-1209)
品牌： Adipogen
产品货号： AG-25T-0119-C020
规格： 20 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-RasGRP2 (phosphorylated) (pSer587), pAb (IG-1209)
  • 别名:
    CalDAG-GEFI; Ras Guanyl Nucleotide-releasing Protein 2; Ras Guanyl Releasing Protein 2; CDC25-like Protein; CDC25L; Calcium and DAG-regulated Guanine Nucleotide Exchange Factor I; MCG7
  • 产品描述:
    RasGRP2 functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating small GTPases, including Rap1/RAS3, through the exchange of bound GDP for GTP. It may also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. The protein is expressed in platelets, neutrophils and T lymphocytes. RasGRP2 functions in aggregation of platelets and adhesion of T lymphocytes and neutrophils probably through inside-out integrin activation. S587 was identified as the major PKA phosphorylation. Phosphorylation of S587 correlated with the inhibitory effect of PKA on Rap1b activation in platelets. In vitro, ERK1/2 phosphorylates RasGRP2 at Ser394 to limit its exchange activity and inhibits its ability to activate the small GTPase Rap1 that ultimately leads to decreased activation of ERK1/2 in cells.
  • 反应种属:
  • 宿主来源:
    Rabbit
  • 实验应用:
    WB
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  • 推荐稀释度:
  • 免疫原:
    Synthetic phosphopeptide corresponding to a partial sequence of human RasGRP2 containing the phosphorylated serine [pS] of the following sequence stretch (-SFSLPRPGRRG[pS]RPPE-IREEEVQTV-).
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  • 保存温度:
    +4°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
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  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS containing 2mg/ml BSA and 0.05% sodium azide.
  • 有效期:
    Stable for at least 6 months after receipt when stored at +4°C.
  • 产地:
    瑞士
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  • 样本类型:
    Liquid. In PBS containing 2mg/ml BSA and 0.05% sodium azide.
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