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anti-Profilin, pAb (IG-706)
品牌： Adipogen
产品货号： AG-25T-0117-C010
规格： 10 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-Profilin, pAb (IG-706)
  • 别名:
    PFN1
  • 产品描述:
    Profilin (PFN1) is a ubiquitous small (12-15kDa) phosphoinositide and poly-L-proline binding protein that plays a role in signal transduction pathways and actin filament dynamics. There are two mammalian profilins with similar biochemical properties. Whereas profilin I appears to be highly expressed in most tissues except for skeletal muscle, profilin II is predominantly expressed in brain and at lower levels also in skeletal muscle, uterus and kidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamic membrane areas like the leading edge and ruffling membranes. Profilin binding to PIP2 interferes with PIP2 hydrolysis by soluble phospholipase C-gamma, an inhibition that can be overcome by tyrosine phosphorylation of PLC-gamma. Besides actin monomer sequestration and stimulation of actin nucleotide exchange, profilin can also promote cellular actin filament growth. Profilin is involved in the actin dependent intracellular motility of cytopathogenic bacteria, the regulation of cell adhesion and possibly also in linking the actin cytoskeleton and endocytosis. Profilin has been found to associate with defined complexes containing proteins such as Arp2/3 or the Rho/Rac pathways constituents ROCK-II and HEM2/NAP1. Defects in PFN1 are the cause of amyotrophic lateral sclerosis 18 (ALS18).
  • 反应种属:
  • 宿主来源:
    Rabbit
  • 实验应用:
    ICC, IHC, WB
  • 靶标/特异性:
  • 同种型:
  • 推荐稀释度:
  • 免疫原:
    Human full-length profilin.
  • 免疫原种属:
  • 克隆性:
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  • 纯化方式:
  • 偶联:
  • 产品浓度:
    100µg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
  • 产品特点:
  • 纯度:
    Antigen affinity purified.
  • 生物活性:
  • 内毒素水平:
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