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产品名称:
anti-ST2 (human), pAb
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别名:
Interleukin-1 Receptor-like 1; IL-1 Receptor-like 1; IL1RL1; Interleukin-33 Receptor; IL-33-Receptor
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产品描述:
ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naïve state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.
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反应种属:
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宿主来源:
Rabbit
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实验应用:
ELISA, FACS, WB
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
Recombinant human soluble ST2.
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产品浓度:
1mg/ml
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
BLUE ICE
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预期分子量:
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产品形式:
liquid
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存储溶液:
Liquid. In PBS containing 0.02% sodium azide.
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有效期:
Stable for at least 6 months after receipt when stored at -20°C.
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产地:
瑞士
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样本类型:
Liquid. In PBS containing 0.02% sodium azide.
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