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PTEN antibody [PTEN/2110]
品牌: GeneTex
产品货号: GTX17980
规格: 100μg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    PTEN antibody [PTEN/2110]
  • 别名:
    BZS , CWS1 , DEC , GLM2 , MHAM , MMAC1 , PTEN , PTEN1 , TEP1 , phosphatase and tensin homolog , 10q23del
  • 产品描述:
  • 反应种属:
    Human
  • 宿主来源:
    Mouse
  • 实验应用:
    IHC-P, Protein Array
  • 靶标/特异性:
  • 同种型:
    IgG2b
  • 推荐稀释度:
  • 免疫原:
    Recombinant full-length human PTEN protein
  • 免疫原种属:
  • 克隆性:
    Monoclonal
  • 克隆号:
    PTEN/2110
  • 纯化方式:
    Protein A/G purified
  • 偶联:
    Unconjugated
  • 产品浓度:
    0.2 mg/ml (Please refer to the vial label for the specific concentration.)
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
  • 运输温度:
    4°C
  • 细胞定位:
  • 预期分子量:
    47
  • 产品形式:
    Liquid
  • 存储溶液:
    10mM PBS, 0.05% BSA
  • 有效期:
  • 产地:
    美国
  • 外观:
  • 生产商:
  • 功能与背景:
    This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
  • URL:
  • 灵敏度:
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  • 检测方法:
  • 样本类型:
    10mM PBS, 0.05% BSA
  • 产品特点:
  • 纯度:
  • 生物活性:
  • 内毒素水平:
  • 来源:
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  • 分子式:
  • 溶解度:
  • PubChem CID:
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