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产品名称:
Rhodopsin Antibody
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别名:
OPN2 Antibody, opsd Antibody, opsin 2 Antibody, opsin 2 rod pigment Antibody, opsin2 Antibody, RHO Antibody, RP4 Antibody, MGC138309 Antibody, Retinitis Pigmentosa 4 Antibody
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产品描述:
Mouse Anti-Bovine Rhodopsin Monoclonal IgG1
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反应种属:
Mammals | Fish | Avian | Amphibians | Shark
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宿主来源:
Mouse
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实验应用:
WB | IHC | ICC/IF | IP | ELISA
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靶标/特异性:
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同种型:
IgG1
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推荐稀释度:
WB (1:1000), IHC (1000); optimal dilutions for assays should be determined by the user.
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免疫原:
Bovine Rhodopsin
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免疫原种属:
Bovine
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克隆性:
Monoclonal
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克隆号:
4D2
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纯化方式:
Protein G Purified
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偶联:
Unconjugated
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产品浓度:
1 mg/ml
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表达系统:
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阳性对照:
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保存温度:
-20ºC
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运输温度:
Blue Ice or 4ºC
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细胞定位:
Membrane
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预期分子量:
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产品形式:
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存储溶液:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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有效期:
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产地:
加拿大
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外观:
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生产商:
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功能与背景:
Rhodopsin consists of the protein moiety opsin and a reversibly covalently bound cofactor, retinal. Opsin, a bundle of seven membrane embedded alpha-helices, binds retinal, a photo reactive chromophore, in a central pocket (2, 3). In addition to being the pigment of the retina that is responsible for both the formation of the photoreceptor cells, its function is to specifically convey information stored in the specific geometry of the chormophore to the surface of the molecule upon light absorption (2). In the active state, rhodopsin activates transduction, a GTP binding protein. Once activated, transduction promotes the hydrolysis of cGMP by phosphodiesterase. Rhodopsin's activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin (4).
Mutations in the rhodopsin gene lead to retinitis pigmentosa, which can be inherited as an autosomal dominant, an autosomal recessive or an X-linked recessive disorder (5).
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URL:
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灵敏度:
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检测范围:
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检测方法:
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样本类型:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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产品特点:
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纯度:
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生物活性:
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内毒素水平:
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来源:
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表达方式:
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Accession #:
NP_001014890.1
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CAS号:
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分子式:
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溶解度:
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PubChem CID: