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产品名称:
HDEL Antibody: Biotin
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别名:
H-D-E-L (his-asp-glu-leu) Antibody, endoplasmic reticulum Antibody, luminal ER protein retention Antibody, KDELR1 Antibody, Endoplasmic reticulum retention signal Antibody
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产品描述:
Mouse Anti-Yeast HDEL Monoclonal IgG2b
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反应种属:
Drosophila | Yeast | Plant
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宿主来源:
Mouse
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实验应用:
WB | ICC/IF
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靶标/特异性:
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同种型:
IgG2b
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推荐稀释度:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
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免疫原:
Raised against a synthetic HDEL peptide corresponding to the C-terminus of yeast Bip
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免疫原种属:
Yeast
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克隆性:
Monoclonal
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克隆号:
2E7
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纯化方式:
Protein G Purified
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偶联:
Biotin
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产品浓度:
1 mg/ml
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表达系统:
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阳性对照:
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保存温度:
Conjugated antibodies should be stored at 4ºC
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运输温度:
Blue Ice or 4ºC
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细胞定位:
Endoplasmic Reticulum
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预期分子量:
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产品形式:
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存储溶液:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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有效期:
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产地:
加拿大
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外观:
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生产商:
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功能与背景:
HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. They act as molecular chaperones, facilitating the assembly of multi-protein complexes; participate in the translocation of polypeptides across cell membranes and to the nucleus; and aid in the proper folding of nascent polypeptide chains (1, 2). GRP 78 is localized in the endoplasmic reticulum (ER), where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains (2). Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually KDEL in animal cells, and HDEL in S.cerevisiae (3). The 2E7 clone recognizes the C-terminal peptide HDEL, a common version of the endoplasmic reticulum retention signal found in yeast, plant, nematode and other ER proteins. 2E7 specifically stains HDEL proteins in barnyard grass, beet, cotton, mung bean, sorghum and wheat (4).
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样本类型:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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