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产品名称:
LAMP2 Antibody: FITC
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别名:
CD107b Antibody, Igp110 Antibody, Igp2 Antibody, Lamp2C Antibody, LampB Antibody, MAC3 Antibody, Lysosome-associated membrane glycoprotein 2 Antibody, LAMP-2 Antibody, Lysosome-associated membrane protein 2 Antibody, CD107 antigen-like family member B Antibody, Lysosomal membrane glycoprotein type B Antibody, LGP-B Antibody
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产品描述:
Rat Anti-Mouse LAMP2 Monoclonal IgG1
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反应种属:
Human | Mouse | Rabbit
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宿主来源:
Rat
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实验应用:
WB | ICC/IF | IP
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靶标/特异性:
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同种型:
IgG1
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推荐稀释度:
WB (1:1000), ICC/IF (1:500); optimal dilutions for assays should be determined by the user.
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免疫原:
Purified preparation of mouse liver lysosomal membranes
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免疫原种属:
Mouse
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克隆性:
Monoclonal
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克隆号:
GL2A7
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纯化方式:
Protein G Purified
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偶联:
FITC
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产品浓度:
1 mg/ml
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表达系统:
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阳性对照:
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保存温度:
Conjugated antibodies should be stored at 4ºC
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运输温度:
Blue Ice or 4ºC
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细胞定位:
Cell Membrane | Endosome | Lysosome | Endosome membrane | Lysosome membrane
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预期分子量:
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产品形式:
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存储溶液:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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有效期:
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产地:
加拿大
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外观:
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生产商:
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功能与背景:
Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3).
LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expresses patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cell-extracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during morphogenesis (4).
Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl-terminal tyrosine based motif (YXXI) (5). This stimulation has also been shown to have an associated release of histamine, leukotriene C4 and prostaglandin D2, which shows that LAMP1 and LAMP2 are activation markers for normal mast cells (5). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (6). LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content (7).
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URL:
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灵敏度:
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检测范围:
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检测方法:
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样本类型:
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
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产品特点:
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纯度:
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生物活性:
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内毒素水平:
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来源:
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表达方式:
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Accession #:
NP_001017959.1
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CAS号:
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分子式:
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溶解度:
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PubChem CID: