anti-alpha-Tubulin (acetylated), mAb (TEU318) - 深圳欣博盛生物科技有限公司

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anti-alpha-Tubulin (acetylated), mAb (TEU318)

品牌： Adipogen

产品货号： AG-20B-0068-C100

规格： 100 ug

报价：

折后价：

数量： - +

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产品名称:

anti-alpha-Tubulin (acetylated), mAb (TEU318)
别名:
产品描述:

Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and beta-tubulin genes, referred to as tubulin isotypes, and the generation of posttranslational modifications (PTMs) on alpha- and beta-tubulin. Tubulin PTMs include the well-known acetylation or phosphorylation, and others that have so far mostly been found on tubulin, detyrosination/tyrosination, polyglutamylation and polyglycylation. These PTMs might have evolved to specifically regulate tubulin and microtubule functions. Tubulin acetylation was discovered on K40 of flagellar alpha-tubulin in Chlamydomonas reinhardtii and is generally enriched on stable microtubules in cells. It is located on the microtubule lumenal surface. As a result of its localization at the inner face of microtubules, K40 acetylation might rather affect the binding of microtubule inner proteins, a poorly characterized family of proteins. Functional experiments in cells have further suggested that K40 acetylation regulates intracellular transport by regulating the traffic of kinesin motors probably by indirect mechanisms. Acetyltransferase alpha-Tat1 (or Mec-17) specifically acetylate alpha-tubulin K40. Acetylation of tubulin by alpha-Tat1 accumulates selectively in stable, long-lived microtubules thus explaining the link between this posttranslational modication and stable microtubules in cells. However, the direct cellular function of K40 acetylation on microtubules is still unclear.
反应种属:
宿主来源:

Purified from concentrated hybridoma tissue culture supernatant.
实验应用:

ICC, WB
靶标/特异性:
同种型:

Mouse IgG1
推荐稀释度:
免疫原:

Tubulin of the Ciliate Euplotes eluted from the 55kDa band of SDS gel.
免疫原种属:
克隆性:
克隆号:

TEU318
纯化方式:
偶联:
产品浓度:

1mg/ml
表达系统:
阳性对照:
保存温度:

-20°C
运输温度:

BLUE ICE
细胞定位:
预期分子量:
产品形式:

liquid
存储溶液:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
有效期:

Stable for at least 1 year after receipt when stored at -20°C.
产地:

瑞士
外观:
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URL:
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样本类型:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
产品特点:
纯度:

>95% (SDS-PAGE)
生物活性:
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