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anti-NLRC3 (mouse), mAb (Eowyn-1)
品牌： Adipogen
产品货号： AG-20B-0067-C100
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-NLRC3 (mouse), mAb (Eowyn-1)
  • 别名:
    NOD3; Nucleotide-binding Oligomerization Protein 3; CARD15-like Protein; Caterpiller Protein 16.2; CLR16.2
  • 产品描述:
    The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of cytosolic pathogen recognition receptors. NLRC3 has the characteristic NOD and leucine-rich repeat configuration with a less well defined CARD. NLRC3 is expressed in T lymphocytes and may be involved in suppression of T cell activation. NLRC3 is a cytoplasmic protein that negatively regulates pro-IL-1beta maturation and inhibits toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB. NLRC3 interacts with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAF6 and activation of NF-kappaB. NLRC3 also reduces STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP) and DNA viruses. NLRC3 associated with both STING and TBK1, impedes STING-TBK1 interaction and downstream type I interferon production.
  • 反应种属:
  • 宿主来源:
    Purified from concentrated hybridoma tissue culture supernatant.
  • 实验应用:
    WB
  • 靶标/特异性:
  • 同种型:
    Mouse IgG1
  • 推荐稀释度:
  • 免疫原:
    Recombinant mouse NLRC3 (card domain).
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    Eowyn-1
  • 纯化方式:
  • 偶联:
  • 产品浓度:
    1mg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
  • 内毒素水平:
  • 来源:
  • 表达方式:
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  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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