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anti-BTLA (human), mAb (6F4)
品牌： Adipogen
产品货号： AG-20B-0049-C100
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    anti-BTLA (human), mAb (6F4)
  • 别名:
    B and T Lymphocyte Associated; Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
  • 产品描述:
    B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory function of HVEM. BTLA also interacts with HVEM in cis, forming a heterodimeric complex in naive T cells that inhibits HVEM-dependent signaling. The cis-interaction between HVEM and BTLA is the predominant form expressed on the surface of naive human and mouse T cells and may be important to limit trans-signaling by LIGHT, BTLA, and CD160 that are expressed in adjacent activated cells.
  • 反应种属:
  • 宿主来源:
    Purified from concentrated hybridoma tissue culture supernatant.
  • 实验应用:
    ELISA, FACS
  • 靶标/特异性:
  • 同种型:
    Rat IgG1
  • 推荐稀释度:
  • 免疫原:
    Ectodomain of human BTLA fused to human IgG Fc.
  • 免疫原种属:
  • 克隆性:
  • 克隆号:
    6F4
  • 纯化方式:
  • 偶联:
  • 产品浓度:
    1mg/ml
  • 表达系统:
  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    BLUE ICE
  • 细胞定位:
  • 预期分子量:
  • 产品形式:
    liquid
  • 存储溶液:
    Liquid. In PBS containing 10% glycerol.
  • 有效期:
    Stable for at least 1 year after receipt when stored at -20°C.
  • 产地:
    瑞士
  • 外观:
  • 生产商:
  • 功能与背景:
  • URL:
  • 灵敏度:
  • 检测范围:
  • 检测方法:
  • 样本类型:
    Liquid. In PBS containing 10% glycerol.
  • 产品特点:
  • 纯度:
    >95% (SDS-PAGE)
  • 生物活性:
  • 内毒素水平:
    <0.001EU/µg purified protein.
  • 来源:
  • 表达方式:
  • Accession #:
  • CAS号:
  • 分子式:
  • 溶解度:
  • PubChem CID:
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