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DBC1 Antibody / Deleted in breast cancer 1 / CCAR2
品牌： NSJ Bio
产品货号： V5241SAF-100UG
规格： 100 ug

报价：
折后价：

数量： - +
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  • 产品名称:
    DBC1 Antibody / Deleted in breast cancer 1 / CCAR2
  • 别名:
  • 产品描述:
    DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein and Cell cycle and apoptosis regulator protein 2 (CCAR2), is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF-Alpha, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF-Alpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER-Alpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.
  • 反应种属:
    Human
  • 宿主来源:
    Mouse
  • 实验应用:
    FACS, IHC-P
  • 靶标/特异性:
  • 同种型:
    Mouse IgG2a
  • 推荐稀释度:
  • 免疫原:
    Recombinant full-length human CCAR2 / KIAA1967 protein was used as the immunogen for the DBC1 antibody.
  • 免疫原种属:
  • 克隆性:
    Monoclonal (mouse origin)
  • 克隆号:
  • 纯化方式:
    Protein A/G affinity
  • 偶联:
  • 产品浓度:
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  • 阳性对照:
  • 保存温度:
    Aliquot the DBC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 运输温度:
  • 细胞定位:
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  • 产品形式:
  • 存储溶液:
    1 mg/ml in 1X PBS; BSA free, sodium azide free
  • 有效期:
  • 产地:
    美国
  • 外观:
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  • 灵敏度:
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  • 检测方法:
  • 样本类型:
    1 mg/ml in 1X PBS; BSA free, sodium azide free
  • 产品特点:
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