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产品名称:
GPX4 antibody [GT1282]
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别名:
glutathione peroxidase 4 , GPx-4 , GSHPx-4 , MCSP , PHGPx , SMDS , snGPx , snPHGPx
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产品描述:
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反应种属:
Human, Mouse, Rat
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宿主来源:
Rabbit
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实验应用:
IP, WB
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靶标/特异性:
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同种型:
IgG
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推荐稀释度:
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免疫原:
A synthesized peptide derived from human GPX4 .
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免疫原种属:
Human
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克隆性:
Monoclonal
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克隆号:
GT1282
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纯化方式:
Purified by affinity chromatography
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偶联:
Unconjugated
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产品浓度:
0.57 mg/ml (Please refer to the vial label for the specific concentration.)
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表达系统:
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阳性对照:
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保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
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运输温度:
4°C
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细胞定位:
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预期分子量:
22
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产品形式:
Liquid
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存储溶液:
PBS pH7.3, 0.05% BSA, 50% Glycerol, 0.02% Sodium azide.
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有效期:
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产地:
美国
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外观:
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生产商:
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功能与背景:
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
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URL:
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检测方法:
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样本类型:
PBS pH7.3, 0.05% BSA, 50% Glycerol, 0.02% Sodium azide.
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纯度:
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