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产品名称:
HMGB1 (rat) (rec.) (His)
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别名:
High Mobility Group Protein B1
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产品描述:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
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反应种属:
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宿主来源:
E. coli
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实验应用:
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靶标/特异性:
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同种型:
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推荐稀释度:
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免疫原:
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偶联:
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
BLUE ICE
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细胞定位:
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预期分子量:
~25-35kDa
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产品形式:
solid
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存储溶液:
Lyophilized from a concentrated sterile solution containing 50mM Tris-Hcl buffer (pH 8.0) and 100mM NaCl.
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有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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产地:
瑞士
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样本类型:
Lyophilized from a concentrated sterile solution containing 50mM Tris-Hcl buffer (pH 8.0) and 100mM NaCl.
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产品特点:
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纯度:
>90% (SDS-PAGE)
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生物活性:
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内毒素水平:
<1EU/mg protein (LAL test; Lonza).
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